Nathan Piland

Ciatrix, Inc

Relationship between vascular system disfunction, neurofluid flow and Alzheimer's progression

#Cardiovascular #Longevity / Anti-aging #Neuroscience #Respiratory #Wellness

How will the SphygmoCor® technology enable, enhance, or accelerate your research?

The amyloidogenic pathological pathway model, suggests that there exists a dynamic equilibrium of Aβ among the three most relevant biological compartments - blood, cerebrospinal fluid (CSF), brain interstitial fluid (ISF). The medical community believes that CSF is propelled by a combination of hydrostatic pressure arising from its continuous production (at rate ~0.4ml/min), by arterial pulsations and by the respiratory cycle. The recent characterizations of the glymphatic and meningeal lymphatic systems in humans call for revaluation of the CSF production pathways and the anatomical routes for CSF–ISF flow and the physiological role that these pathways play in CNS health. We identified and scientifically proved the existence of a third neurofluid oscillator while studying the brain's glymphatic clearance system, an oscillator controlled by our spine motion. Using advanced fNIR brain imaging techniques developed by University of Oulu in Finland, we can now clearly measure oscillations of CSF caused by spine motion. Integrating SphygmoCor® ability to measure central blood pressures (cBP), vascular stiffness, vascular age, and heart stress into our research will provide invaluable insights into the cardio vascular component of CSF pulsations, enriching our understanding and therapeutic interventions. With precise digital vascular biomarkers, we aim to elucidate the intricate relationship between vascular system disfunction, neurofluid flow and Alzheimer's progression. The non-invasiveness of SphygmoCor® aligns perfectly with our mission to develop non-invasive Alzheimer's disease treatments. Furthermore, collaboration with CardieX offers a strategic partnership, fostering innovation and driving meaningful advancements in Alzheimer's treatment.

Executive Summary

Ciatrix identified and scientifically proved the existence of a third neurofluid oscillator while studying the brain's glymphatic clearance system, an oscillator controlled by our spine motion. Using advanced fNIR brain imaging techniques developed by University of Oulu in Finland, we can now clearly measure oscillations of cerebrospinal fluid (CSF) caused by spine motion. Brain health and homeostasis depend on CSF circulation to remove metabolic waste and supply required nutrients. Our therapy is designed to significantly augment cerebrospinal fluid (CSF) circulation to improve brain health crippled by lack of sleep, stress, & neurodegenerative diseases, such as MCI, Alzheimer’s, Parkinson’s and more. The body has natural self-defense mechanisms against disease. Ciatrix design therapies backed by scientific evidence, to augment those natural mechanisms to prevent, stop, and restore itself of underlying disease. Ciatrix's mission is to discover new ways to treat brain diseases, especially Alzheimer's. Our clinical studies and trials aim to test the efficacy of a novel medical device, Fluere® PRO, in restoring and significantly augmenting brains glymphatic clearance, identified in 2012 as the key system to clean metabolic brain waste. Removing brains metabolic buildup, including abnormally accumulated Amyloid- β (Aβ) peptide, is proven to improve the cognition, restore brain functions and stop progression of AD. Our project is divided to two clinical trials focusing on augmenting glymphatic clearance as a possible treatment of Alzheimer's disease.

Research Setting

Ciatrix boasts a dynamic and accomplished “outsiders” team poised to drive groundbreaking research in neurodegenerative diseases. Led by our CEO and CSO, a recognized physicist with multiple successful exits, including a notable acquisition by Phillips, our team brings unparalleled expertise in innovation and strategic leadership. Backing our CEO is a seasoned COO with extensive global manufacturing experience, ensuring seamless execution of our research initiatives. Complementing our core leadership is our Chief Strategy Officer, hailing from prestigious medtech companies like Medtronic and Becton Dickinson, equipped with a comprehensive skill set spanning Regulatory, Quality, R&D, Marketing, and Market Access. Our legal counsel, with a background at Boston Scientific, safeguards legal aspects, while an attorney with dual expertise in law and neurology oversees our IP strategy. Furthermore, our clinical studies benefit from the guidance of a practicing neurologist, who also serves as our clinical advisor and principal investigator for international trials while serving as the Head of Memory Center for the International Neurodegenerative Disorders Research Center. We've cultivated strong partnerships, particularly with the University of Minnesota and University of Oulu, where ongoing research continues. Leveraging these collaborations, along with dedicated staff support, we ensure the seamless execution of our research objectives.