Body Compositional and Cardiometabolic Effects of Testosterone Therapy in Obese Men with Severe Obstructive Sleep Apnea: A Randomized Placebo-Controlled Trial
October 1, 2012Refractory Hypertension: Evidence of Heightened Sympathetic Activity as a Cause of Antihypertensive Treatment Failure.
May 18, 2015Low Testosterone in Men Predicts Impaired Arterial Elasticity and Microvascular Function
Men experience an age-related decline in sex hormones, termed “andropause,” linked to decreased bone density, muscle mass, and increased cardiovascular risk. Corrigan et al. investigated the relationship between testosterone levels and vascular function in 242 men, with 25% having low testosterone. Low levels correlated with microvascular and endothelial dysfunction, increased arterial stiffness, and cardiovascular risk factors. Testosterone negatively correlated with augmentation index (AIX), indicating elevated vascular biomarkers with lower testosterone. Low testosterone is also associated with age, hypertension, diabetes, dyslipidemia, and body size, and reduced microvascular response. These findings underscore testosterone’s role in vascular health and its association with cardiovascular risk factors in aging men.