Drug and Device Development

Harnessing Vascular Biomarkers for Next-Generation Therapies

Transform Drug Discovery with Vascular Phenotyping

Vascular phenotyping utilizes vascular biomarkers to evaluate arterial stiffness and cardiovascular function. This approach offers critical insights into the effects of new compounds and devices on the vascular system, aiding in the identification of potential efficacy and adverse reactions. Early quantification of these biomarkers allows researchers to more precisely predict clinical outcomes, speeding up the development of promising candidates and reducing the risk of costly late-stage failures.

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Vascular Biomarkers Explained

Vascular biomarkers are revolutionizing not only cardiovascular health management but also clinical research and personal wellness strategies.

These critical indicators offer a comprehensive evaluation of the cardiovascular system's health across a broad spectrum, from clinical trials to individual health monitoring. By assessing key markers such as endothelial function, arterial stiffness, and coronary flow reserve, they enable a nuanced understanding of cardiovascular risks and conditions.

This valuable insight facilitates early intervention, personalized health optimization, and the development of targeted treatments in clinical settings, significantly advancing patient care and wellness initiatives.

Brachial Blood Pressure

What it Is
Brachial blood pressure measures the pressure of blood at the brachial artery using a blood pressure cuff.

Why it Matters
High blood pressure is a major risk factor for heart disease and stroke, both of which are leading causes of death in the US.

Central Blood Pressure

What it Is
Calculated using pulse wave analysis and a traditional brachial cuff, central blood pressure measures pressure at the root of the aorta.

Why it Matters
Central blood pressure reflects key vascular issues such as arterial stiffness, which makes it a more accurate predictor of subclinical cardiovascular disease than traditional brachial blood pressure alone.

Subendocardial Viability Ratio

What it Is
Subendocardial viability ratio measures the supply of blood that flows to your inner heart muscle in relation to demand.

Why it Matters
SEVR offers insight into how well a person’s heart can handle the stress of exercise.

Augmentation Pressure

What it Is
Augmentation pressure refers to the increase in central aortic pressure caused pressure wave reflection.

Why it Matters
A marker of arterial stiffness, elevated augmentation pressure is associated with cardiovascular risk factors as well as increased cardiovascular morbidity and mortality.

Augmentation Index

What it Is
An indirect measure of arterial stiffness that increases with age, augmentation index reflects the burden stiff arteries place on the heart.

Why it Matters
Chronic stress on the heart and the cardiovascular system can lead to heart failure and hypertrophy (enlarged heart).

Central Pulse Pressure

What it Is
The height of pressure at the heart, central pulse pressure shows the pressure to which key organs like the heart, brain, and kidneys are exposed.

Why it Matters
Central pulse pressure helps identify the risk of end organ damage to key organs like the brain, kidney and heart.

Medical Grade Heart Rate

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Pulse Wave Velocity

What it Is
Pulse wave velocity measures arterial stiffness.

Why it Matters
Increases in arterial stiffness are generally based on the loss of elasticity in the aorta artery walls over time and increases the strain on the heart from heightened pressures. Increased aortic stiffness using PWV is a validated predictor of cardiovascular events and all-cause mortality.

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Clinical Trial & Research Partners

Enhance The Success of Every Trial

Monitoring vascular biomarkers can help identify specific profiles that predict patient responses to treatments, enhancing trial stratification and ensuring that only likely beneficiaries are included. This precision improves trial outcomes and reduces risks and costs associated with ineffective treatments. By leveraging these biomarkers, researchers can swiftly adjust treatment protocols to optimize safety and efficacy. Overall, the use of vascular biomarkers in clinical trials enables more personalized, efficient, and effective development of new medical interventions.

Clinical Trials Management

Our comprehensive clinical trial management service encompasses a suite of offerings tailored to streamline the collection and analysis of vascular biomarkers. From protocol design to data management and analysis, we ensure precise and efficient capture of vascular health data throughout your trial. Our cutting-edge technology enables real-time insights into patient responses, enhancing trial accuracy and accelerating the pathway to regulatory approval and market entry for new therapies.

With our expertise in clinical trial management and vascular biomarker analysis, we provide a seamless and efficient solution to meet your trial's needs, ensuring compliance with regulatory requirements and achieving scientific and medical objectives.

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Traditional Clinical Trials

Sphygmocor XCEL offers precise, non-invasive measurements of vascular biomarkers including central blood pressure and arterial stiffness. By integrating these measurements into clinical trials, the device enhances the precision of patient selection and efficacy assessments, ultimately accelerating the development pipeline and improving the safety profile of new therapies.

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Decentralized Clinical Trials

CONNEQT Pulse streamlines remote health data collection, gathering real-time physiological and vascular biomarker data without the need for participants to visit clinical sites. This approach enhances participant engagement, reduces logistical burdens, and expands participant reach to remote areas. By improving data quality and quantity while accelerating trial timelines, CONNEQT Pulse facilitates more adaptable, inclusive, and diverse clinical trials.

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Capture Ambulatory Data

Oscar 2 excels as a leading ambulatory monitor, capturing vascular biomarkers continuously over 24 hours in non-clinical settings. By monitoring blood pressure dynamics and arterial health in real-world conditions, it enhances the reliability of vascular biomarker assessments, expediting the development of new therapies.

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