Metabolic Health

Examine the Interplay between Cardiovascular and Metabolic Health

with Digital Vascular Biomarkers

Fast Facts

98M

adults in the US have prediabetes, more than 8 in 10 don’t know they have it.1

38M

adults in the US have diabetes, 1 in 5 don’t know they have it.2

2X

Medical costs for people with diabetes are more than twice as high as for people who don’t have diabetes.3

The Connection Between Arterial Stiffening and Metabolic Health

  • Hwang HS, Ko KP, Kim MG, et al.

    Subjects with abnormal metabolic conditions have increased arterial stiffness independent of age and BP which may contribute to the development of cardiovascular disease.

    Hwang HS, Ko KP, Kim MG, et al.
    Clinical Hypertension
  • Firmino, Wende, Gregorio, et al.

    Patients with prediabetes present early markers of cardiac dysfunction and arterial stiffness.

    Firmino, Wende, Gregorio, et al.
    Annals of Vascular Surgery
  • Monika Starzak, Agata Stanek, Grzegorz K. Jakubiak et. al.

    Increased arterial stiffness (AS) can predict the development of cardiovascular disease both in the general population and in patients with Metabolic Syndrome (MS).

    Monika Starzak, Agata Stanek, Grzegorz K. Jakubiak et. al.
    Int J Environ Res Public Health

Arterial Stiffness and Metabolic Health

Metabolic health and arterial stiffness are closely linked, significantly affecting cardiovascular wellness. Conditions like insulin resistance, abnormal lipid levels, and obesity can accelerate arterial stiffness, increasing the risk of hypertension and heart disease. Optimal metabolic health, achieved through lifestyle modifications and medical management, is essential for reducing arterial stiffness and improving heart health.

Research Highlights

Diabetes and Cardiovascular Risk

Vascular biomarkers play a crucial role in managing diabetes by facilitating the early detection of cardiovascular risks linked to metabolic disorders, evaluating the effectiveness of treatments, and personalizing medical approaches. These biomarkers help in understanding the impact of metabolic factors on vascular aging and can predict future cardiovascular events, enabling proactive and targeted interventions to improve overall health outcomes.

Utility of Vascular Biomarkers in Metabolic Health

  • Prince CT, Secrest AM, Mackey RH, Arena VC, et al.

    PWA measures, particularly AP and SEVR, are associated with both renal damage and poor renal function in type 1 diabetes.

    Prince CT, Secrest AM, Mackey RH, Arena VC, et al.
    Diabetes & Vascular Disease Research
  • Marcon D, Tagetti A, Piona C, Giontella A, et al.

    The independent association between cBP and markers of subclinical vascular damage underlines the importance of haemodynamic factors in the development of early signs of macrovascular disease in T1D patients.

    Marcon D, Tagetti A, Piona C, Giontella A, et al.
    Journal of Hypertension
  • Tougaard NH, Theilade S, Winther SA, Tofte N, et al.

    [In people with type 1 diabetes mellitus,] higher carotid-femoral pulse wave velocity (cfPWV) was associated with increased hazard of progression in albuminuria, decline in eGFR ≥30%, cardiovascular event, mortality, and the composite renal end point.

    Tougaard NH, Theilade S, Winther SA, Tofte N, et al.
    Journa of American Heart Association

Vascular Biomarkers Explained

Vascular biomarkers are revolutionizing not only cardiovascular health management but also clinical research and personal wellness strategies.

These critical indicators offer a comprehensive evaluation of the cardiovascular system's health across a broad spectrum, from clinical trials to individual health monitoring. By assessing key markers such as endothelial function, arterial stiffness, and coronary flow reserve, they enable a nuanced understanding of cardiovascular risks and conditions.

This valuable insight facilitates early intervention, personalized health optimization, and the development of targeted treatments in clinical settings, significantly advancing patient care and wellness initiatives.

Brachial Blood Pressure

What it Is
Brachial blood pressure measures the pressure of blood at the brachial artery using a blood pressure cuff.

Why it Matters
High blood pressure is a major risk factor for heart disease and stroke, both of which are leading causes of death in the US.

Central Blood Pressure

What it Is
Calculated using pulse wave analysis and a traditional brachial cuff, central blood pressure measures pressure at the root of the aorta.

Why it Matters
Central blood pressure reflects key vascular issues such as arterial stiffness, which makes it a more accurate predictor of subclinical cardiovascular disease than traditional brachial blood pressure alone.

Subendocardial Viability Ratio

What it Is
Subendocardial viability ratio measures the supply of blood that flows to your inner heart muscle in relation to demand.

Why it Matters
SEVR offers insight into how well a person’s heart can handle the stress of exercise.

Augmentation Pressure

What it Is
Augmentation pressure refers to the increase in central aortic pressure caused pressure wave reflection.

Why it Matters
A marker of arterial stiffness, elevated augmentation pressure is associated with cardiovascular risk factors as well as increased cardiovascular morbidity and mortality.

Augmentation Index

What it Is
An indirect measure of arterial stiffness that increases with age, augmentation index reflects the burden stiff arteries place on the heart.

Why it Matters
Chronic stress on the heart and the cardiovascular system can lead to heart failure and hypertrophy (enlarged heart).

Central Pulse Pressure

What it Is
The height of pressure at the heart, central pulse pressure shows the pressure to which key organs like the heart, brain, and kidneys are exposed.

Why it Matters
Central pulse pressure helps identify the risk of end organ damage to key organs like the brain, kidney and heart.

Medical Grade Heart Rate
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Pulse Wave Velocity

What it Is
Pulse wave velocity measures arterial stiffness.

Why it Matters
Increases in arterial stiffness are generally based on the loss of elasticity in the aorta artery walls over time and increases the strain on the heart from heightened pressures. Increased aortic stiffness using PWV is a validated predictor of cardiovascular events and all-cause mortality.

 
cbpCentral Blood Pressure

What it Is
Calculated using pulse wave analysis and a traditional brachial cuff, central blood pressure measures pressure at the root of the aorta.

Why it Matters
Central blood pressure reflects key vascular issues such as arterial stiffness, which makes it a more accurate predictor of subclinical cardiovascular disease than traditional brachial blood pressure alone.

 
bbpBrachial Blood Pressure

What it Is
Brachial blood pressure measures the pressure of blood at the brachial artery using a blood pressure cuff.

Why it Matters
High blood pressure is a major risk factor for heart disease and stroke, both of which are leading causes of death in the US.

 
sevrSubendocardial Viability Ratio

What it Is
Subendocardial viability ratio measures the supply of blood that flows to your inner heart muscle in relation to demand.

Why it Matters SEVR offers insight into how well a person’s heart can handle the stress of exercise.

 
medical grade heart rateMedical Grade Heart Measurement

What it Is
A beat-to-beat heart rate measurement on par with standard ECG-based methods.

Why it Matters
A consistently high resting heart rate may be a sign of coronary heart disease and is associated with a greater risk of stroke.

 
cppCentral Pulse Pressure

What it Is
The height of pressure at the heart, central pulse pressure shows the pressure to which key organs like the heart, brain, and kidneys are exposed.

Why it Matters
Central pulse pressure helps identify the risk of end organ damage to key organs like the brain, kidney and heart.

 
cppPulse Wave Velocity

What it Is
Pulse wave velocity measures arterial stiffness.

Why it Matters
Increases in arterial stiffness are generally based on the loss of elasticity in the aorta artery walls over time and increases the strain on the heart from heightened pressures. Increased aortic stiffness using PWV is a validated predictor of cardiovascular events and all-cause mortality.

 
augmentation pressureAugmentation Pressure

What it Is
Augmentation pressure refers to the increase in central aortic pressure caused pressure wave reflection.

Why it Matters
A marker of arterial stiffness, elevated augmentation pressure is associated with cardiovascular risk factors as well as increased cardiovascular morbidity and mortality.

 
augmentation indexAugmentation Index

What it Is
An indirect measure of arterial stiffness that increases with age, augmentation index reflects the burden stiff arteries place on the heart.

Why it Matters
Chronic stress on the heart and the cardiovascular system can lead to heart failure and hypertrophy (enlarged heart).

Hover over each biomarker above to learn more

Incorporate Vascular Biomarkers in the Management of Diabetes

Download Reimbursement Guide

In-Clinic

  • Enhance cardiovascular risk stratification and personalize management plans for diabetic patients.
  • Tailor and adjust treatment strategies, improving both metabolic and vascular health outcomes.
  • Reimbursable with CPT 93050.

At Home

  • Empower patients to actively manage their health by tracking changes in their biomarkers.
  • Integration with telemedicine to maintains an ongoing patient-provider interaction and enhances personalized care.
  • Reimbursable with CPT 9945x & 99091.

SphygmoCor® XCEL

Capture comprehensive central hemodynamics and arterial stiffness insights at point-of-care and in clinical trials.

Explore XCEL

CONNEQT Pulse

Monitor arterial health insights with ease at home and on-the-go.

Explore Pulse

Oscar 2

Gold standard in 24-hour central hemodynamics and ambulatory blood pressure monitoring (ABPM).

Explore Oscar 2

1, 2, 3 CDC Diabetes Fast Facts

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