Analysis of Arterial Stiffness and Sexual Function after Adding on PCSK9 Inhibitor Treatment in Male Patients with Familial Hypercholesterolemia: A Single Lipid Center Real-World Experience

While statins offer benefits for lipid profiles, sexual function, and arterial stiffness in the general population, patients with familial hypercholesterolemia (FH) still face early cardiovascular disease onset. Purrello and colleagues examined 30 males with FH to assess the effects of lipid-lowering treatment, specifically PCSK9 inhibitors, on sexual function and arterial stiffness (measured by pulse wave velocity, PWV). Their findings revealed that PCSK9 inhibitor therapy significantly improved both sexual function and the relationship between sexual function, lipid profiles, and PWV. These results suggest that adding PCSK9 inhibitor therapy can further enhance vascular and sexual function in males with FH.