Cardiex Intellectual Property

The proprietary technology and IP portfolio of the Cardiex group companies covers a significant range of applications from clinically validated methods of quantifying hemodynamic parameters for assessment of cardiovascular health to interactive and interpretative analysis for consumer healthcare management.

Gold standard FDA-cleared device for the measurement of central blood pressure and cardiovascular risk parameters (Standard FDA “predicate device”).
Proprietary IP & technology in cardiac load, athletic capacity, arterial stiffness, arterial age, and other consumer health diagnostic parameters published in over 2,400+ peer-reviewed studies.
26 issued and non-expired U.S. and international patents and 8 pending non-provisional U.S. and international patent applications.
31 U.S. and international trademark registrations and 22 pending U.S. and international trademark applications.
Expanding licensing and co-development opportunities in broad medical and consumer health segments.
Future applications in “Quantified Athlete”, remote patient monitoring, and broad health categories.

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Patent Title	Patent Number	Description	Related Technology	Status	Countries
Simplified Systolic and Pulse Pressure Method	7628758	The more clinically relevant blood pressure (BP) at the heart differs significantly from BP at the upper arm. BP at the heart can only be measured directly through an invasive procedure. This patent provides a simple and non-invasive method of estimating BP at the heart from a non-invasive pulse recording on the wrist.	BP monitoring device	Patent	Europe, Japan, US
Method of Distinguishing between Vasoconstriction and Vasodilatation as a Cause of Hypotension	7442169	This patent provides a method to distinguish between low cardiac output and severe organ damage in low BP acute emergencies using arterial pulse recordings. The method is a simple and quick tool to correctly identify the cause of a substantial drop in BP during acute emergency situations using waveform analysis.	Emergency Medical device	Patent	US
Method of Estimating Pulse Wave Velocity	8273030	This patented method estimates the “gold standard” arterial stiffness indicator, PWV (pulse waveform velocity), from one single arterial pulse recording on the wrist, arm, or finger. This method has the advantage of measuring PWV from one single pulse instead of the usual two-pulse method that requires multiple sensors’ recordings.	Arterial Stiffness Devices	Patent	US
Methods for Determining Cardiac Output	8679025	Cardiac output is a clinically important parameter in order to assess a patient’s cardiac function and assist in cardiac diagnosis. Known cardiac output measurements require an extensive and invasive procedure. This patent provides a simpler method of estimating cardiac output from a non-invasive arterial pulse recording.	Cardiac output device, ICU monitoring devices	Patent	US
Optimization of Pacemaker Settings	8112160	Pacemakers require an adjustment of the time setting based on cardiac ejection period. This patented method uses arterial pulse waveform features to detect the correct ejection period for pacemaker timing. It provides an accurate and easy way to program a pacemaker.	Pacemakers	Patent	US
Estimating Central Aortic Pressure from Brachial Cuff Pulse	9314170	Non-invasively estimating the heart’s pressure and pressure waveform with features related to cardiac function and arterial properties by using a conventional BP cuff inflated to low pressure. The patent provides a non-invasive, simple, and operator-independent tool to clinically diagnose cardiovascular system and estimate risk of having heart disease which otherwise require an invasive procedure. The method in principle can be implemented in BP cuff devices and improve their capability.	BP Cuff Devices, Cardiovascular devices	Patent	Europe, Japan, US
Measuring Central Pressure with a Brachial Cuff	9974450	Non-invasively estimating the heart’s pressure and pressure waveform with features related to cardiac function and arterial properties by using a conventional BP cuff inflated to different pressure values. The patent provides a non-invasive, simple, and operator-independent tool to clinically diagnose cardiovascular system and estimate risk of having heart disease which otherwise require an invasive procedure. The method in principle can be implemented in BP cuff devices and improve their capability.	BP Cuff Devices, Cardiovascular devices	Patent	US
Central Pressure Waveform with Features Preserved	15/953,707	Non-invasively estimating heart’s pressure and pressure waveform with features related to cardiac function and arterial properties by using a conventional BP cuff inflated to different pressure values. The patent provides a non-invasive, simple, and operator-independent tool that captures arterial waveform features to clinically diagnose cardiovascular system and estimate risk of having heart disease which otherwise require an invasive procedure. The method in principle can be implemented in BP cuff devices and improve their capability.	BP Cuff Devices, Cardiovascular devices	Patent Application (Patent Pending)	US
Optimization of Pacemaker Settings With R-wave Detection	9220903	Pacemakers require adjustment of the time setting based on a cardiac ejection period. This patented method uses arterial pulse waveform features with a feature from an ECG signal to detect the correct ejection period for pacemaker timing. It provides an accurate and easy way to program a pacemaker.	Pacemakers	Patent	US
Optimization of Pacemaker Settings with Electrogram	15/141,923	Pacemakers require adjustment of the time setting based on a cardiac ejection period. This patented method uses features of an arterial pulse waveform with all features from an ECG signal to detect the correct ejection period for pacemaker timing. It provides an accurate and easy way to program pacemaker.	Pacemakers	Patent Application (Patent Pending)	US
Non-invasive Brachial Blood Pressure Measurement	15/907,693	Blood pressure at the arm as measured by a conventional BP cuff device is different from BP measured invasively in the brachial artery at the arm. This patent is a non-invasive method to estimate the more accurate and invasively measured BP by using BP cuff waveform. It can be implemented in BP cuff devices to improve their accuracy.	BP Cuff Devices	Patent Application (Patent Pending)	Global, US
Central Aortic Blood Pressure and Waveform Calibration Method	15/923,092	Non-invasive estimation of pressure at the heart is dependant on a BP cuff device measurement of BP at the arm, which differs from the invasive measurement of BP, thereby producing error in the estimation. This patent reduces the error and improves the accuracy of the non-invasive estimation of BP at the heart, which is more relevant to cardiac function and arterial properties than BP at the arm.	BP Cuff Devices	Patent Application (Patent Pending)	Global, US
Non-invasive Blood Pressure Measurement	15/943,970	This patent provides a novel method of estimating BP using features from arterial pulse waveform without using a cuff. The method can be implemented on wearable devices.	BP monitoring device, Wearable devices	Patent Application (Patent Pending)	Global, US

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