TECHNOLOGY & INTELLECTUAL PROPERTIES


The proprietary technology and IP portfolio of the CardieX group companies covers a significant range of applications from clinically validated methods of quantifying hemodynamic parameters for assessment of cardiovascular health to interactive and interpretative analysis for consumer healthcare management.

  • Gold standard FDA-cleared device for the measurement of central blood pressure and cardiovascular risk parameters (Standard FDA “predicate device”).
  • Current IP and technology focused on cardiovascular health.
  • Significant trademarks in consumer and wearable sectors.
  • Future applications in “Quantified Athlete”, remote patient monitoring, and broad health categories.
  • Proprietary IP & technology in cardiac load, athletic capacity, arterial stiffness, arterial age, and other consumer health diagnostic parameters.
  • Expanding licensing and co-development opportunities in broad medical and consumer health segments.
  • Over 1000 published peer-reviewed studies.
  • 13 USA patents covering significant applications in cardiovascular health and consumer wearables.
Patent TitlePatent NumberDescriptionRelated TechnologyStatusCountriesrelated_tech_hfiltercountry_hfilter
Simplified Systolic and Pulse Pressure Method7628758

The more clinically relevant blood pressure (BP) at the heart differs significantly from BP at the upper arm. BP at the heart can only be measured directly through an invasive procedure. This patent provides a simple and non-invasive method of estimating BP at the heart from a non-invasive pulse recording on the wrist.

BP monitoring devicePatentEurope, Japan, USbp_monitoreurope japan us
Method of Distinguishing between Vasoconstriction and Vasodilatation as a Cause of Hypotension7442169

This patent provides a method to distinguish between low cardiac output and severe organ damage in low BP acute emergencies using arterial pulse recordings. The method is a simple and quick tool to correctly identify the cause of a substantial drop in BP during acute emergency situations using waveform analysis.

Emergency Medical devicePatentUSemer_deviceus
Method of Estimating Pulse Wave Velocity8273030

This patented method estimates the “gold standard” arterial stiffness indicator, PWV (pulse waveform velocity), from one single arterial pulse recording on the wrist, arm, or finger. This method has the advantage of measuring PWV from one single pulse instead of the usual two-pulse method that requires multiple sensors’ recordings.

Arterial Stiffness DevicesPatentUSart_devicesus
Methods for Determining Cardiac Output8679025

Cardiac output is a clinically important parameter in order to assess a patient’s cardiac function and assist in cardiac diagnosis. Known cardiac output measurements require an extensive and invasive procedure. This patent provides a simpler method of estimating cardiac output from a non-invasive arterial pulse recording.

Cardiac output device, ICU monitoring devicesPatentUScard_out_device icu_mon_devicesus
Optimization of Pacemaker Settings8112160

Pacemakers require an adjustment of the time setting based on cardiac ejection period. This patented method uses arterial pulse waveform features to detect the correct ejection period for pacemaker timing. It provides an accurate and easy way to program a pacemaker.

PacemakersPatentUSpacemakersus
Estimating Central Aortic Pressure from Brachial Cuff Pulse9314170

Non-invasively estimating the heart’s pressure and pressure waveform with features related to cardiac function and arterial properties by using a conventional BP cuff inflated to low pressure. The patent provides a non-invasive, simple, and operator-independent tool to clinically diagnose cardiovascular system and estimate risk of having heart disease which otherwise require an invasive procedure. The method in principle can be implemented in BP cuff devices and improve their capability.

BP Cuff Devices, Cardiovascular devicesPatentJapan, USbp_cuff cardio_devicesjapan us
Measuring Central Pressure with a Brachial Cuff9974450

Non-invasively estimating the heart’s pressure and pressure waveform with features related to cardiac function and arterial properties by using a conventional BP cuff inflated to different pressure values. The patent provides a non-invasive, simple, and operator-independent tool to clinically diagnose cardiovascular system and estimate risk of having heart disease which otherwise require an invasive procedure. The method in principle can be implemented in BP cuff devices and improve their capability.

BP Cuff Devices, Cardiovascular devicesPatentUSbp_cuff cardio_devicesus
Central Pressure Waveform with Features Preserved15/953,707

Non-invasively estimating heart’s pressure and pressure waveform with features related to cardiac function and arterial properties by using a conventional BP cuff inflated to different pressure values. The patent provides a non-invasive, simple, and operator-independent tool that captures arterial waveform features to clinically diagnose cardiovascular system and estimate risk of having heart disease which otherwise require an invasive procedure. The method in principle can be implemented in BP cuff devices and improve their capability.

BP Cuff Devices, Cardiovascular devicesPatent Application (Patent Pending)USbp_cuff cardio_devicesus
Optimization of Pacemaker Settings With R-wave Detection9220903

Pacemakers require adjustment of the time setting based on a cardiac ejection period. This patented method uses arterial pulse waveform features with a feature from an ECG signal to detect the correct ejection period for pacemaker timing. It provides an accurate and easy way to program a pacemaker.

PacemakersPatentUSpacemakersus
Optimization of Pacemaker Settings with Electrogram15/141,923

Pacemakers require adjustment of the time setting based on a cardiac ejection period. This patented method uses features of an arterial pulse waveform with all features from an ECG signal to detect the correct ejection period for pacemaker timing. It provides an accurate and easy way to program pacemaker.

PacemakersPatent Application (Patent Pending)USpacemakersus
Non-invasive Brachial Blood Pressure Measurement15/907,693

Blood pressure at the arm as measured by a conventional BP cuff device is different from BP measured invasively in the brachial artery at the arm. This patent is a non-invasive method to estimate the more accurate and invasively measured BP by using BP cuff waveform. It can be implemented in BP cuff devices to improve their accuracy.

BP Cuff DevicesPatent Application (Patent Pending)Global, USbp_cuffglobal us
Central Aortic Blood Pressure and Waveform Calibration Method15/923,092

Non-invasive estimation of pressure at the heart is dependant on a BP cuff device measurement of BP at the arm, which differs from the invasive measurement of BP, thereby producing error in the estimation. This patent reduces the error and improves the accuracy of the non-invasive estimation of BP at the heart, which is more relevant to cardiac function and arterial properties than BP at the arm.

BP Cuff DevicesPatent Application (Patent Pending)Global, USbp_cuffglobal us
Non-invasive Blood Pressure Measurement15/943,970

This patent provides a novel method of estimating BP using features from arterial pulse waveform without using a cuff. The method can be implemented on wearable devices.

BP monitoring device, Wearable devicesPatent Application (Patent Pending)Global, USbp_monitor wearablesglobal us