Effect of Testosterone Replacement Therapy on Arterial Stiffness in Older Hypogonadal Men

Male hypogonadism (low testosterone) is a recognized contributor to endothelial dysfunction and arterial stiffening, increasing cardiovascular mortality risk. Yaron et al. investigated the effects of testosterone replacement therapy on arterial stiffness (pulse wave velocity (PWV)), in hypogonadal men. They found that hypogonadal men exhibited significantly higher PWV, which decreased significantly within 48 hours of initiating testosterone replacement therapy and remained reduced over 3 months of treatment. These findings underscore the critical role of testosterone levels in modulating both functional and structural arterial responses.