Effects of Organic and Inorganic Nitrate on Aortic and Carotid Hemodynamics in Heart Failure and Preserved Ejection Fraction

A research group led by Julio Chirinos assessed effects of organic and inorganic nitrate on patients with heart failure with preserved ejection fraction (HFpEF). The team found that nitroglycerin caused vasodilation and reduced blood pressure, while inorganic nitrate consistently reduced wave reflections without affecting blood pressure, suggesting that central hemodynamic differences are likely related to the differential clinical effects of these agents on HFpEF patients.