The Effects of Induced Hypogonadism on Arterial Stiffness, Body Composition, and Metabolic Parameters in Males with Prostate Cancer

Androgen deprivation therapy (ADT) in prostate cancer induces hypogonadism with uncertain vascular effects. Smith et al. investigated ADT’s impact on vascular biomarkers in 22 patients, including central blood pressure (cBP) and augmentation index (AIx). They found ADT-induced hypogonadism increased both cBP and AIx, suggesting elevated systemic arterial stiffness. Post-treatment cessation revealed reversible effects on arterial compliance. These findings underscore ADT’s implications for vascular health, emphasizing the importance of monitoring vascular biomarkers during treatment to mitigate potential cardiovascular risks effectively.