Arterial Insights for Early Detection & Precision Intervention of Preeclampsia

In-Clinic, At Home, On-the-Go

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Fast Facts

3.2X

higher cost multiple for preeclampsia compared to uncomplicated pregnancy

81.1%

Percentage of deliveries in 2019 (US) had 1 or more moderate risks for preeclampsia

75%

Percentage of pregnant women at increased risk of preeclampsia do not take aspirin as prescribed

Preeclampsia and Arterial Stiffening Go Hand-in-Hand

"Having had preeclampsia added ~6 years to the vascular age of affected women and early vascular aging was significantly more likely to be present in women with severe preeclampsia than in nonsevere preeclampsia or controls."
Werlang, Paquin, and Coutinho
Journal of American Heart Association, 2023
"Before gestational hypertension sets in… early alterations can be detected through arterial stiffness parameters’ measurements, such as pulse wave velocity (PWV) and augmentation index (AIx)."
Turi et al
Diagnostics, 2022
"A meta-analysis and systematic review of 36 studies found arterial stiffness and waveform reflection measurements consistently increased among pregnant women that developed preeclampsia."
Osman et al
Journal of Hypertension, 2018
"Arterial stiffness predicted pre-eclampsia earlier and with greater ability than blood pressure, ultrasound indices or angiogenic biomarkers."
Phan et al
BJOG, 2023

Add Arterial Stiffness Assessments to Prenatal Care

In-Clinic

Assess preeclampsia risk at 1st visit & initiate home monitoring for high-risk patients.
Surveillance during regular visits through 6-wk postpartum visit
Reimbursable with CPT 93050.

At Home

Ongoing monitoring to detect alterations in arterial functions and structure.
Reinforce aspirin regimen.
Reimbursable with CPT 9945x & 99091

SphygmoCor XCEL

Blood pressures (brachial & central)
Coronary flow reserve
Arterial stiffness (Pulse Wave Analysis & Pulse Wave Velocity)

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CONNEQT Pulse

Blood pressures (brachial & central)
Coronary flow reserve
Arterial stiffness (Pulse Wave Analysis)

Explore Pulse

CONNEQT Band

Blood pressures (brachial & central)
Coronary flow reserve
Arterial stiffness (Pulse Wave Analysis)

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Vascular Biomarkers Measured

			CONNEQT Pulse	CONNEQT Band

	Heart Rate (HR)	A beat-to-beat heart rate measurement on par with standard ECG-based methods. A consistently high resting heart rate may be a sign of coronary heart disease.
	Brachial Blood Pressure	The pressure of blood at the brachial artery in the upper arm. High brachial blood pressure is a major risk factor for heart disease and stroke.		P
	Central Blood Pressure (SP & DP)	The pressure of blood at the root of the aorta in the heart. cBP is a more accurate predictor of subclinical cardiovascular disease than traditional brachial blood pressure alone.		P
	Central Pulse Pressure (PP)	The pressure which key organs like the heart, brain, and kidneys experience. It is used to identify the risk of end organ damage to major organs.		P
	Augmentation Pressure (AP)	A marker indicating how stiff one’s artery is. Elevated augmentation pressure is associated with cardiovascular risk factors.		P
	Augmentation Index (AIx)	Another marker indicating how stiff one’s artery is. It reflects the burden stiff arteries place on the heart.
	Subendocardial Viability Ratio (SEVR)	The supply of blood that flows to your inner heart muscle in relation to demand. It offers insight into how well a person’s heart can handle the stress of exercise.
	Pulse Pressure Amplification (PPA)	The increase in amplitude of arterial pulse waves as they travel from central to peripheral arteries and provides insights into arterial stiffness, wave reflection, as well as the efficiency of blood flow distribution.	P
	Pulse Wave Velocity (PWV)	The speed at which the arterial pulse travels through the circulatory system, a key indicator of arterial stiffness.
	SphygmoCor Reference Age	Estimated arterial age based on central pressure and arterial stiffness parameters of healthy individuals without cardiovascular and metabolic diseases.	P	P
P = displayed in provider portal

Utility of Vascular Biomarkers in Maternal Health

"In a study of 1,600 pregnant women, central blood pressure was found to be the best predictor for the later development of preeclampsia, while brachial blood pressure was not."
Marozio et al
Journal of Hypertension, 2019
"A one-point higher AIX was associated with 0.3-day reduced time-to-delivery. AIx is associated with time-to-delivery and other outcomes in pregnancy."
Fullerton et al
Hypertension in Pregnancy, 2014
"Compared to traditional diagnostic markers for preeclampsia, pulse wave velocity has shown to be a superior marker, demonstrating a detection rate of 81% for all cases and 82% for early-onset, at a fixed 10% false-positive rate."
Katsipi et al
Hypertension Research, 2014
"Vascular alteration can be detected in the second trimester. Pulse wave velocity changepoint was detected at 14-17 weeks and augmentation index increased at 18-21 weeks in women went on to develop preeclampsia."
Phan et al
Metabolism, 2021
"Postpartum women who have had severe preeclampsia have more pronounced arterial stiffness parameters including pulse wave velocity, augmentation index, central systolic pressure, and pulse pressure amplification"
Belmar Vega et al
Nefrologia, 2024