Academia/Research

Shaping Tomorrow's Advancements with Vascular Biomarkers

Discover Novel Insights and Breakthroughs

Vascular biomarkers are crucial in academic research, providing broad utility across disciplines. They enhance understanding of cardiovascular disease mechanisms, support early diagnosis and prognosis, and aid in developing more effective diagnostic tools and therapies. In population studies and epidemiology, these biomarkers identify trends and risk factors, effectively bridging basic research and clinical practice to transform patient care.

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Vascular Biomarkers Explained

Vascular biomarkers are revolutionizing not only cardiovascular health management but also clinical research and personal wellness strategies.

These critical indicators offer a comprehensive evaluation of the cardiovascular system's health across a broad spectrum, from clinical trials to individual health monitoring. By assessing key markers such as endothelial function, arterial stiffness, and coronary flow reserve, they enable a nuanced understanding of cardiovascular risks and conditions.

This valuable insight facilitates early intervention, personalized health optimization, and the development of targeted treatments in clinical settings, significantly advancing patient care and wellness initiatives.

Brachial Blood Pressure

What it Is
Brachial blood pressure measures the pressure of blood at the brachial artery using a blood pressure cuff.

Why it Matters
High blood pressure is a major risk factor for heart disease and stroke, both of which are leading causes of death in the US.

Central Blood Pressure

What it Is
Calculated using pulse wave analysis and a traditional brachial cuff, central blood pressure measures pressure at the root of the aorta.

Why it Matters
Central blood pressure reflects key vascular issues such as arterial stiffness, which makes it a more accurate predictor of subclinical cardiovascular disease than traditional brachial blood pressure alone.

Subendocardial Viability Ratio

What it Is
Subendocardial viability ratio measures the supply of blood that flows to your inner heart muscle in relation to demand.

Why it Matters
SEVR offers insight into how well a person’s heart can handle the stress of exercise.

Augmentation Pressure

What it Is
Augmentation pressure refers to the increase in central aortic pressure caused pressure wave reflection.

Why it Matters
A marker of arterial stiffness, elevated augmentation pressure is associated with cardiovascular risk factors as well as increased cardiovascular morbidity and mortality.

Augmentation Index

What it Is
An indirect measure of arterial stiffness that increases with age, augmentation index reflects the burden stiff arteries place on the heart.

Why it Matters
Chronic stress on the heart and the cardiovascular system can lead to heart failure and hypertrophy (enlarged heart).

Central Pulse Pressure

What it Is
The height of pressure at the heart, central pulse pressure shows the pressure to which key organs like the heart, brain, and kidneys are exposed.

Why it Matters
Central pulse pressure helps identify the risk of end organ damage to key organs like the brain, kidney and heart.

Medical Grade Heart Rate
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Pulse Wave Velocity

What it Is
Pulse wave velocity measures arterial stiffness.

Why it Matters
Increases in arterial stiffness are generally based on the loss of elasticity in the aorta artery walls over time and increases the strain on the heart from heightened pressures. Increased aortic stiffness using PWV is a validated predictor of cardiovascular events and all-cause mortality.

 
cbpCentral Blood Pressure

What it Is
Calculated using pulse wave analysis and a traditional brachial cuff, central blood pressure measures pressure at the root of the aorta.

Why it Matters
Central blood pressure reflects key vascular issues such as arterial stiffness, which makes it a more accurate predictor of subclinical cardiovascular disease than traditional brachial blood pressure alone.

 
bbpBrachial Blood Pressure

What it Is
Brachial blood pressure measures the pressure of blood at the brachial artery using a blood pressure cuff.

Why it Matters
High blood pressure is a major risk factor for heart disease and stroke, both of which are leading causes of death in the US.

 
sevrSubendocardial Viability Ratio

What it Is
Subendocardial viability ratio measures the supply of blood that flows to your inner heart muscle in relation to demand.

Why it Matters SEVR offers insight into how well a person’s heart can handle the stress of exercise.

 
medical grade heart rateMedical Grade Heart Measurement

What it Is
A beat-to-beat heart rate measurement on par with standard ECG-based methods.

Why it Matters
A consistently high resting heart rate may be a sign of coronary heart disease and is associated with a greater risk of stroke.

 
cppCentral Pulse Pressure

What it Is
The height of pressure at the heart, central pulse pressure shows the pressure to which key organs like the heart, brain, and kidneys are exposed.

Why it Matters
Central pulse pressure helps identify the risk of end organ damage to key organs like the brain, kidney and heart.

 
cppPulse Wave Velocity

What it Is
Pulse wave velocity measures arterial stiffness.

Why it Matters
Increases in arterial stiffness are generally based on the loss of elasticity in the aorta artery walls over time and increases the strain on the heart from heightened pressures. Increased aortic stiffness using PWV is a validated predictor of cardiovascular events and all-cause mortality.

 
augmentation pressureAugmentation Pressure

What it Is
Augmentation pressure refers to the increase in central aortic pressure caused pressure wave reflection.

Why it Matters
A marker of arterial stiffness, elevated augmentation pressure is associated with cardiovascular risk factors as well as increased cardiovascular morbidity and mortality.

 
augmentation indexAugmentation Index

What it Is
An indirect measure of arterial stiffness that increases with age, augmentation index reflects the burden stiff arteries place on the heart.

Why it Matters
Chronic stress on the heart and the cardiovascular system can lead to heart failure and hypertrophy (enlarged heart).

Hover over each biomarker above to learn more

Clinical Trial & Research Partners

Anthem
AstraZeneca
Barnes Jewish Hospital
Bayer
Brigham Health
Bristol-Myers Squibb
Cedars-Sinai
Cleveland Clinic
Covance
Duke University Hospital
Invaryant
Massachusetts General Hospital
Mayo Clinic
Mount Sinai
New York Presbyterian
Northwestern Memorial Hospital
Novartis
Penn Medicine
Power
Samsung
Stanford Medicine
SunTech Medical
UCLA Health
UCSF Medical Center
University of Michigan Health System
UPMC
Vanderbilt University Medical Center

40 Years

Founded on 40 years of hemodynamics studies, Validated by 20+ years of research.

2,400+

The SphygmoCor technology has been independently validated by researchers worldwide and supported studies that resulted in over 2,400+ peer-reviewed publications.

SphygmoCor® Technology

Our pioneering technology was enabled by more than 40 years of hemodynamic studies of the cardiovascular system and set the foundation for noninvasive measurement of vascular biomarkers including central aortic pressures and arterial stiffness indices.

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Clinical Investigations

Sphygmocor XCEL provides accurate, non-invasive assessments of key vascular biomarkers such as central blood pressure and arterial stiffness. By evaluating the mechanical properties of arteries and the effects of blood flow on arterial walls, this device enables researchers to investigate the complex interactions that contribute to cardiovascular diseases. Such insights are crucial for developing personalized treatment plans, monitoring the effectiveness of interventions, and understanding how vascular changes relate to broader health outcomes.

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Real World Insights

CONNEQT Pulse significantly streamlines data collection, enabling frequent and real-time capture of physiological and vascular biomarker data in remote and home environments. This device eliminates the need for participants to visit research sites, simplifying logistics and enhancing engagement. By facilitating regular data collection across a wide geographic area, CONNEQT Pulse not only improves study quality but also broadens the scope of research possibilities in everyday settings.

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Around-the-Clock Data

Oscar 2 stands out as a top ambulatory monitor, continuously capturing vascular biomarkers over 24 hours in non-clinical environments. By tracking blood pressure dynamics and arterial health in real-world settings, it significantly boosts the reliability of vascular biomarker evaluations. This enhanced accuracy accelerates the discovery of new insights, as it supplies researchers with more relevant data from everyday conditions.

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