Vitamin D supplementation for the improvement of vascular function in patients with chronic kidney disease: a meta-analysis of randomized controlled trials

Vitamin D deficiency is linked to chronic kidney disease (CKD) progression and vascular dysfunction. Dou and colleagues conducted a meta-analysis of seven randomized controlled trials involving 429 CKD patients. Results showed that Vitamin D treatment correlated with a significant decrease in pulse wave velocity, indicating reduced arterial stiffness. Interestingly, no significant differences in blood pressure were observed. Therefore, these findings suggest that vitamin D supplementation may improve vascular health by reducing arterial stiffness, independent of blood pressure changes.