Personalized Treatment Regimen Following Pulse Wave Analysis

41-Year-Old Male with Untreated Hypertension

Patient Medical History

41-year-old sedentary male
No comorbidities
No current Rx regimen

Initial Digital Vascular Biomarker Assessment

Brachial Blood Pressure	144/64 mmHg
Central Systolic Blood Pressure	109 mmHg
Central Pulse Pressure Amplification	77%

Initial Assessment Interpretation

This male patient’s substantial pulse pressure amplification (brachial 78 mmHg/central 44 mmHg; 77%) and the central systolic BP < 124 mmHg argues against drug therapy.

Figure 6. Central Pressure Waveform

BBP indicates brachial blood pressure systolic/diastolic; CBP, central blood pressure systolic/diastolic; CPP, central pulse pressure; AIx, augmentation index; HR, heart rate; bpm, beats per minute.

Intervention

An exercise regimen was recommended and followed.

Follow Up Digital Vascular Biomarker Assessment

Brachial Blood Pressure	124/62 mmHg
Central Systolic Blood Pressure	99 mmHg
Central Pulse Pressure Amplification	68%

Follow up Assessment Interpretation

Following a three month exercise regimen, this male patient shows brachial systolic pressure improvement and continued substantial pulse pressure amplification (brachial 62mmHg/central 37mmHg; 68%). No additional pharmacologic therapies were prescribed and he was encouraged to continue the exercise program.

This clinical case study supports two important clinical decisions. One was not to pharmacologically treat a modest brachial systolic pressure elevation. The other was to support the value of exercise, which improved the patient’s brachial blood pressure without loss of the advantageous central pressure profile.

*Townsend RR et al. Journal of Clinical Hypertension. 2015; 17:7, 503–513.
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Figure 7. Central Pressure Waveform